While designing anything, these are the questions that I ask myself every single time.
Asking these questions right at the onset of the design process makes it easier to keep certain aspects of the problem in focus.
Currently I am working in a lab which explores the idea of using modern technology to follow television series in a more cohesive manner. We were discussing the target audience for a project and then someone succinctly asked the following questions.
Who am I looking at?
Why should I care?
What is going on?
Why is it happening?
I think I am going to ask these questions from now!